Mondal et al — Muscular Metastasis of Melanoma in Contralateral Limb
Rare case: distant intramuscular metastasis in the contralateral limb, 5+ years after treatment of melanoma on the other arm; original SLNB was negative. No lymph node involvement in this case — included for context on late/atypical melanoma spread patterns, not as direct nodal-drainage evidence.
Verified verbatim (Discussion)
MM typically metastasises locally to other cutaneous areas, subcutaneous tissue or lymph nodes, and to distant sites including the liver, brain and bone. In a retrospective study spanning 14 years and 67 cases of cutaneous MM which had developed metastases, Tejera-Vaquerizo et al found that 55% developed lymph node metastasis in the first instance, with 14.9% developing distant metastasis. Similarly, Meier et al reviewed 466 cases of metastatic cutaneous MM and found 50.2% presented in lymph nodes and 28.1% presented with distant metastasis… development of distant metastases occurred on average 25 months following initial MM treatment, regardless of whether the primary cutaneous MM had lymph node involvement at the time of primary treatment.
My take
Only tangentially relevant (no nodal drainage angle) — keep as a “for completeness” background reference on melanoma metastatic patterns rather than a core citation.